Author

Lorenzo Lafranchi

Science for Life LaboratoryORCID 0000-0001-8234-4162Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:CRISPR screen· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Simon J. ElsässeriD· 3 shared Anna Spinner· 2 shared Dörte SchlesingeriD· 2 shared Glancis L. Raja AruliD· 2 shared Alberto M. ArenasiD· 1 shared Birthe MeinekeiD· 1 shared Carmen NavarroiD· 1 shared Carmen Navarro Luzon· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

Simon J. ElsässerORCID

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3 papers

Recent·Most cited

Cell BiologyNucleic Acids ResearchPeer-reviewedOct 28, 2025

Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response

Lorenzo Lafranchi, Glancis L. Raja Arul, Alberto M. Arenas…·Simon J. Elsässer

The paper uses pooled overexpression screens to identify PIPPI, a novel microprotein involved in the ER stress response, by screening sORFs for cytoprotective effects against 6-thioguanine.

4 citations

humanexperimental assay

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Molecular BiologyiSciencePeer-reviewedJan 23, 2025

A large-scale sORF screen identifies putative microproteins and provides insights into their interaction partners, localisation and function

Dörte Schlesinger, Christopher Dirks, Carmen Navarro…·Simon J. Elsässer

The paper performs a CRISPR/Cas9 screen of sORFs to identify microproteins involved in cancer cell growth, finding several candidates with functional roles and localization data.

28 citationstop 1%

humanCRISPR screen

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Synthetic BiologyACS Chemical BiologyPeer-reviewedSep 27, 2018

Methanomethylophilus alvus Mx1201 provides basis for mutual orthogonal pyrrolysyl tRNA/aminoacyl-tRNA synthetase pairs in mammalian cells

Birthe Meineke, Johannes Heimgärtner, Lorenzo Lafranchi, Simon J. Elsässer

The paper identifies a new pyrrolysyl tRNA/aminoacyl-tRNA synthetase pair from M. alvus Mx1201 that is orthogonal to Mma PylRS/PylT in mammalian cells, enabling site-specific ncAA incorporation via distinct stop codons.

85 citations

humanexperimental assay

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