Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response
Lorenzo Lafranchi, Glancis L. Raja Arul, Alberto M. Arenas, Anna Spinner, Kovi R Shrung, Maximilian Hornisch, Dörte Schlesinger, Carmen Navarro Luzon, Linus Brinkenstråhle, Rui Shao, Ilaria Piazza, Janne Lehtiö, Rui Mamede Branca, Simon J. Elsässer
The paper uses pooled overexpression screens to identify PIPPI, a novel microprotein involved in the ER stress response, by screening sORFs for cytoprotective effects against 6-thioguanine.
Nucleic Acids Research · Oct 28, 2025Peer-reviewedCell Biology