Dörte Schlesinger

Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response

The paper uses pooled overexpression screens to identify PIPPI, a novel microprotein involved in the ER stress response, by screening sORFs for cytoprotective effects against 6-thioguanine.

KDM5 demethylases suppress R-loop-mediated viral mimicry and DNA damage in breast cancer cells

This study shows that KDM5 demethylases suppress R-loop formation in breast cancer cells, reducing DNA damage and enhancing immune-related gene expression without affecting normal cells.

A large-scale sORF screen identifies putative microproteins and provides insights into their interaction partners, localisation and function

The paper performs a CRISPR/Cas9 screen of sORFs to identify microproteins involved in cancer cell growth, finding several candidates with functional roles and localization data.