Author

Sriram Vijayraghavan

Medical University of South CarolinaORCID 0000-0001-8248-7833Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 3 Assay:DNA methylation· 2 Research Focus:variant calling· 2 Assay:whole-exome sequencing· 2 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Natalie SainiiD· 3 shared Piotr A. MieczkowskiiD· 3 shared Latarsha Porcher· 2 shared Samuel BeckeriD· 2 shared Alessandra Ruggiero· 1 shared George S. HannaiD· 1 shared James McCollum· 1 shared Mark T. HamanniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersGenetics

Natalie SainiORCID

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3 papers

Recent·Most cited

GeneticsNucleic Acids ResearchPeer-reviewedJul 19, 2025

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairing

Sriram Vijayraghavan, Alessandra Ruggiero, Samuel Becker…·Natalie Saini

This study shows methylglyoxal mutagenizes single-stranded DNA through Rev1-mediated slippage and mispairing, with mutations enriched in tumor datasets.

9 citations

yeastDNA methylation

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GeneticsGeneticsPeer-reviewedDec 21, 2024

Multiple DNA repair pathways prevent acetaldehyde-induced mutagenesis in yeast

Latarsha Porcher, Sriram Vijayraghavan, Yashvi Patel…·Natalie Saini

This study identifies DNA repair pathways that prevent acetaldehyde-induced mutagenesis in yeast and corroborates findings in human liver cancers.

11 citations

yeastwhole-exome sequencing

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GeneticsNucleic Acids ResearchPeer-reviewedJul 1, 2022

Acetaldehyde makes a distinct mutation signature in single-stranded DNA

Sriram Vijayraghavan, Latarsha Porcher, Piotr A. Mieczkowski, Natalie Saini

This study shows acetaldehyde causes strand-biased G[->]T mutations on single-stranded DNA via Polζ bypass and identifies a unique mutation signature in alcohol-related cancers.

44 citationstop 5%

yeastDNA methylation

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