Roy Dayne Mayfield

Brain transcriptomic signatures for mood disorders and suicide phenotypes: an anterior insula and subgenual ACC network postmortem study

The paper identifies molecular signatures in the anterior insula and subgenual ACC brain network associated with mood disorders and suicide outcomes using postmortem RNA-sequencing data.

Integrative genomics approach identifies glial transcriptomic dysregulation and risk in the cortex of individuals with Alcohol Use Disorder

The paper identifies glial transcriptomic dysregulation and genetic risk in the cortex of individuals with Alcohol Use Disorder using single nuclei RNA-sequencing.

Alcohol induces concentration-dependent transcriptomic changes in oligodendrocytes

This study shows that alcohol induces concentration-dependent transcriptomic changes in oligodendrocytes, affecting pathways like myelination and inflammation.

Divergent gene expression in alcohol and opioid usedisorders results in consistent alterations in functional networks in the Dorsolateral Prefrontal Cortex

This study identifies divergent gene expression in AUD and OUD but finds shared biological pathways in the dorsolateral prefrontal cortex, suggesting potential therapeutic targets.

A Systematic Review and Meta-analysis on the Transcriptomic Signatures in Alcohol Use Disorder

This study performs a cross-species meta-analysis of transcriptomic data from AUD patients and animal models to identify common differentially expressed genes and pathways involved in AUD.

Transcriptome analysis of alcohol dependence and stress interactions in the nucleus of the solitary tract

This study identifies transcriptomic changes in the nucleus of the solitary tract (NTS) in response to alcohol dependence and stress, highlighting IFN signaling and specific genes linked to increased alcohol consumption.

Single cell transcriptome profiling of the human alcohol-dependent brain

This study uses snRNA-seq to analyze transcriptomes of 16,000 nuclei from human prefrontal cortex in alcoholics and controls, identifying cell type-specific gene expression changes associated with alcohol dependence.

Allele-Specific Expression and High-Throughput Reporter Assay Reveal Functional Variants in Human Brains with Alcohol Use Disorders

The paper identifies functional variants in human brains with alcohol use disorders by combining allele-specific expression analysis with high-throughput reporter assays.

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

The paper identifies 129 differentially expressed genes in the PFC of alcoholics and links them to pathways and modules associated with alcohol dependence and consumption.

Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice

This study shows that TLR3 activation with poly(I:C) increases alcohol intake in mice, with effects dependent on TLR3 but not MyD88.