Yuan‐I Chen

A High-Throughput Platform for Rapid Adaptation of DNA Aptamers to SARS-CoV-2 Evolution

This paper develops a high-throughput platform to rapidly adapt DNA aptamers against evolving SARS-CoV-2 variants, identifying mutants with improved binding affinity and specificity.

A live tumor fragment platform to assess immunotherapy response in core needle biopsies while addressing challenges of tumor heterogeneity

This paper introduces a live tumor fragment platform to assess immunotherapy response in core needle biopsies, showing it can detect T-cell responses and mitigate tissue heterogeneity challenges.

Ketomimetic Nutrients Trigger a Dual Metabolic Defense in Breast Cancer Cells

This study shows that a ketomimetic medium increases chemoresistance and invasiveness of breast cancer cells through hypersialylation and lipid synthesis pathways.

Multiscale effective connectivity analysis of brain activity using neural ordinary differential equations

This paper introduces a deep learning model to analyze multiscale brain activity dynamics and demonstrates its effectiveness in capturing causal interactions across scales.

Inferring system-level brain communication through multi-scale neural activity

This paper introduces a model to infer brain communication across scales and shows it outperforms existing methods in accuracy and predictive power.