Juline Poirson

This study identifies induced-proximity drugs that target β-catenin in colorectal cancer by recruiting Casein kinase I, leading to its degradation and inhibiting tumor growth.

The paper maps binary SARS-CoV-2 protein interactions with host proteins, identifying key processes like immune signaling and ubiquitination, and suggests therapeutic targets.

The paper identifies potent protein degraders and stabilizers using proteome-scale induced proximity screens and shows they outperform existing E3 ligases.