Author

Lucie Wolf

German Cancer Research CenterORCID 0000-0003-4159-0978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Aarushi Vasudeva· 1 shared Alena IvanovaiD· 1 shared Bianca PokrandtiD· 1 shared Britta BrüggeriD· 1 shared Carina SeidliD· 1 shared Carsten StichtiD· 1 shared Christof NiehrsiD· 1 shared Diego Aponte-Santamaria· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Aarushi Vasudeva

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Phosphorylation-driven Targeted Protein Degradation of Oncogenic β-catenin

Lucie Wolf, Juline Poirson, Graham Dickson and Hugh MacLeod, Sichun Lin, Youngchang Kim, Maira P. Almeida, Mikko Taipale, Stéphane Angers

This study identifies induced-proximity drugs that target β-catenin in colorectal cancer by recruiting Casein kinase I, leading to its degradation and inhibiting tumor growth.

bioRxiv · Mar 18, 2026 · PreprintMolecular Biology

Secretion and signaling properties of Wnt11 and Wnt3 are determined by their N-terminus

Oksana Voloshanenko, Nachiket Dhonnar, Diego Aponte-Santamaria, Carina Seidl, Lucie Wolf, Dominique Kranz, Alena Ivanova, Eddye J. Figueroa Marquez, Bianca Pokrandt, Iris Augustin, Irmgard M. Sinning, Fillip Port, Christof Niehrs, Britta Brügger, Michael Boutros

This study shows that the N-terminus of Wnt proteins determines their secretion and signaling properties, with Wnt11's N-terminus enabling Evi/Wls-independent secretion and Frizzled 6 activation.

bioRxiv · Jul 2, 2025 · PreprintCell Biology

Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling

Sina V. Barysch, Nicolas Stankovic‐Valentin, Tim Miedema, Samir Karaca, Judith Doppel, Thiziri Nait Achour, Aarushi Vasudeva, Lucie Wolf, Carsten Sticht, Henning Urlaub, Frauke Melchior

The paper identifies transient deSUMOylation of IRF2BP proteins as critical for regulating immediate early gene expression in EGFR signaling.

EMBO Reports · Jan 22, 2021Peer-reviewedMolecular Biology