Author

Neil Shephard

University of SheffieldORCID 0000-0001-8301-6857Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:dimensionality reduction· 1 Organism:E. coli· 1 Research Focus:spatial domain detection· 1 Organism:Xenopus· 1

Frequent Co-Authors

Alice L. B. PyneiD· 2 shared Laura WigginsiD· 2 shared Max C. GamilliD· 2 shared Sylvia WhittleiD· 2 shared Thomas E. CatleyiD· 2 shared Agnieszka GambusiD· 1 shared Daniel BradyiD· 1 shared Dušan RačkoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiophysics

Alice L. B. PyneORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BiophysicsComputational and Structural Biotechnology JournalPeer-reviewedMar 1, 2026

Deep Learning-Enhanced TopoStats for the Automated Quantification of DNA and Complex Biomolecular Structures

Sylvia Whittle, Tobias A Firth, Max C. Gamill…·Alice L. B. Pyne

The paper introduces an enhanced TopoStats tool using deep learning to automate and quantify AFM data, enabling detailed structural analysis of biomolecules.

DOI 10.34133/csbj.0227

imagingdeep learning

𝕏 PostBluesky

BiophysicsNature CommunicationsPeer-reviewedJul 1, 2025

Under or Over? Tracing Complex DNA Structures with High-Resolution Atomic Force Microscopy

Elizabeth P. Holmes, Max C. Gamill, James Iain Provan…·Alice L. B. Pyne

This paper introduces a high-throughput AFM-based pipeline using deep learning to trace DNA topology, revealing new insights into DNA structures and their interactions.

21 citationstop 2%

XenopusE. coli

𝕏 PostBluesky