Under or Over? Tracing Complex DNA Structures with High-Resolution Atomic Force Microscopy
Elizabeth P. Holmes, Max C. Gamill, James Iain Provan, Laura Wiggins, Renáta Rusková, Sylvia Whittle, Thomas E. Catley, Kavit H. S. Main, Neil Shephard, Helen E. Bryant, Neville S. Gilhooly, Agnieszka Gambus, Dušan Račko, Sean D. Colloms, Alice L. B. Pyne
This paper introduces a high-throughput AFM-based pipeline using deep learning to trace DNA topology, revealing new insights into DNA structures and their interactions.
Nature Communications · Jul 1, 2025Peer-reviewedBiophysics