Author
University of SheffieldORCID 0009-0008-9164-9513Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Matthew D. Newton, Thomas E. Catley, Sylvia Whittle…·Simon J. Boulton
This study shows TRF2 mediates force-resistant tethering of telomeric DNA repeats, which may be a step in T-loop formation.
Sylvia Whittle, Tobias A Firth, Max C. Gamill…·Alice L. B. Pyne
The paper introduces an enhanced TopoStats tool using deep learning to automate and quantify AFM data, enabling detailed structural analysis of biomolecules.
Elizabeth P. Holmes, Max C. Gamill, James Iain Provan…·Alice L. B. Pyne
This paper introduces a high-throughput AFM-based pipeline using deep learning to trace DNA topology, revealing new insights into DNA structures and their interactions.
Bradley Diggines, Sylvia Whittle, Indresh Yadav…·Alice L. B. Pyne
This study uses high-resolution AFM and image analysis to analyze the topology of kinetoplast DNA, revealing structural properties and changes upon digestion.