Alice L. B. Pyne

This study shows TRF2 mediates force-resistant tethering of telomeric DNA repeats, which may be a step in T-loop formation.

This study visualizes DNA-DNA pairing using AFM and MD simulations, showing ion-mediated groove alignment as a mechanism for homologous recognition.

The paper introduces an enhanced TopoStats tool using deep learning to automate and quantify AFM data, enabling detailed structural analysis of biomolecules.

The paper identifies cytosolic DNA structures in MSI CRC that enhance STING activation and anti-tumor immunity, suggesting potential for improved DNA-based therapies.

This paper introduces a high-throughput AFM-based pipeline using deep learning to trace DNA topology, revealing new insights into DNA structures and their interactions.

This study shows that DNA-binding proteins and nicks increase R-loop formation in vitro, revealing their roles in R-loop dynamics and initiation.

This study uses high-resolution AFM and image analysis to analyze the topology of kinetoplast DNA, revealing structural properties and changes upon digestion.