Tianran Peng

The paper functionally characterizes enhancers in totipotent-like cells using reporter assays and integrates with epigenomic and transcriptomic data to show their role in ZGA gene transcription.

The paper shows that embryonic stem cells use asymmetric division in a two-cell-like state to rejuvenate and maintain lineage immortality by segregating DNA damage.

This study shows that P53 regulates G1-phase progression in ground state ESCs by controlling RB expression, and its inactivation leads to loss of RB and uncontrolled proliferation.