Author

Xuzhao Zhai

Sun Yat-sen University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Boyan Huang· 2 shared Boyen HuangiD· 2 shared Dan LiangiD· 2 shared Jiekai CheniD· 2 shared Ling Li· 2 shared Shu Sun· 2 shared Tianran PengiD· 2 shared Yating ZhuiD· 2 shared

Activity by Year

2022-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersDevelopmental Biology

Boyan Huang

Mutual co-authors in cluster

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4 papers

Recent·Most cited

High-throughput functional characterization of enhancers in totipotent-like cells

Lingyue Yang, Tianran Peng, Yating Zhu, Xuzhao Zhai, Boyen Huang, Hai Zhou, Tao Zhang, Ling Li, Tao Zhang, Yunxia Cao, Jiekai Chen, Dan Liang, Jiangping He, Man Zhang

The paper functionally characterizes enhancers in totipotent-like cells using reporter assays and integrates with epigenomic and transcriptomic data to show their role in ZGA gene transcription.

Nature Communications · Sep 1, 2026Peer-reviewedDevelopmental Biology

β-Catenin Drives Apical-Basal Polarization to facilitate TE lineage commitment In Vitro and In Vivo

Jie Hu, Xuzhao Zhai, Yating Zhu, Boyan Huang, Shu Sun, jiali fu, wenwen shi, Ling Li, Dan Liang, Wakam Chang

This study shows β-catenin drives apical-basal polarization and TE lineage commitment in mouse embryos in vitro and in vivo.

bioRxiv · Jun 9, 2026 · PreprintDevelopmental Biology

Asymmetric Division in a Two-Cell-Like State Rejuvenates Embryonic Stem Cells

王欣怡, Hong Fu, Qingyang Sun, Boyan Huang, Zhe Xu, Xuzhao Zhai, Chuncao Deng, Laru Peng, Mengdan Zhang, Tianran Peng, An Gong, Jiasui Liu, Zhengzhi Zou, Guangjin Pan, Jiekai Chen, , Mingwei Min

The paper shows that embryonic stem cells use asymmetric division in a two-cell-like state to rejuvenate and maintain lineage immortality by segregating DNA damage.

Cell Research · Feb 3, 2026Peer-reviewedCell Biology

Highly efficient generation of blastocyst-like structures from mouse totipotent blastomere-like cells

Pengfei Zhang, Xuzhao Zhai, Boyen Huang, Shu Sun, Wenjing Wang, Man Zhang

The paper demonstrates that TBLCs can efficiently generate blastocyst-like structures with 80% efficiency, outperforming EPSCs in blastoid formation.

bioRxiv · Mar 1, 2022 · PreprintDevelopmental Biology