Author

Simon Mobach

Amsterdam UMC Location University of AmsterdamORCID 0000-0001-8320-214XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Reggie BosmaiD· 2 shared Andy ChevignéiD· 1 shared Arnon Philip KateriD· 1 shared Caitrin CruddeniD· 1 shared Claudia V. Perez AlmeriaiD· 1 shared Daphne JurriensiD· 1 shared Desislava N. NeshevaiD· 1 shared Eric ElderingiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPharmacology & Toxicology

Reggie BosmaORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyMolecular PharmacologyPeer-reviewedOct 26, 2025

Inhibition of constitutive activity of the atypical chemokine receptor ACKR3 by the small-molecule inverse agonist VUF16840

Reggie Bosma, Desislava N. Nesheva, Merel Rijnsburger…·Rob Leurs

This study characterizes VUF16840 as a selective inverse agonist of ACKR3 that inhibits constitutive and chemokine-induced signaling by stabilizing the inactive conformation of the receptor.

5 citations

humanexperimental assay

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedJun 11, 2025

Disruption of basal CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms

Simon Mobach, Nick D. Bergkamp, Ziliang Ma…·Raimond Heukers

This study shows that disrupting CXCR4 oligomers in lymphoid cancers reduces migration, survival signaling, and tumor growth, while sensitizing cells to venetoclax.

6 citations

humanproteomics

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