Author

Claudia V. Perez Almeria

Vrije Universiteit AmsterdamORCID 0000-0002-7312-8529Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Caitrin CruddeniD· 2 shared Marco H. SideriusiD· 2 shared Martine J. SmitiD· 2 shared Raimond HeukersiD· 2 shared Arnon Philip KateriD· 1 shared Brian F. VolkmaniD· 1 shared Carsten HoffmanniD· 1 shared Chérine BecharaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Caitrin CruddenORCID

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2 papers

Recent·Most cited

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies

Claudia V. Perez Almeria, Omolade Otun, Roman R. Schlimgen, Thomas D Lamme, Lotte Di Niro, Caitrin Crudden, Jan Paul Bebelman, Noureldine Youssef, Lejla Musli, Shawn E. Jenjak, Vladimir Bobkov, Julia Drube, Carsten Hoffmann, Brian F. Volkman, Sébastien Granier, , Martine J. Smit

This study uses inverse agonistic nanobodies to reveal constitutive activity of ACKR3, showing it drives non-canonical signaling and basal cell motility, suggesting therapeutic potential.

Nature Communications · Dec 2, 2025Peer-reviewedBiochemistry

Disruption of basal CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms

Simon Mobach, Nick D. Bergkamp, Ziliang Ma, Marco Vincent Haselager, Stephanie Mareike Anbuhl, Daphne Jurriens, Jelle van den Bor, Ziming Wang, Caitrin Crudden, Jamie Lee Roos, Claudia V. Perez Almeria, Rick A. Boergonje, Martin J. Lohse, Reggie Bosma, Eric Eldering, , Raimond Heukers

This study shows that disrupting CXCR4 oligomers in lymphoid cancers reduces migration, survival signaling, and tumor growth, while sensitizing cells to venetoclax.

Proceedings of the National Academy of Sciences · Jun 11, 2025Peer-reviewedBiochemistry