Defective synapto-nuclear signaling contributes to motoneuron vulnerability in SOD1-ALS
Kamil Grycz, Cedric Jan, Piotr Zawistowski, Bartosz Wasicki, Burak Özkan, Oumayma Aousji, Riccardo Sirtori, Claudia Fallini, Guillaume Caron, Simon M. Danner, Francesco Roselli, Daniel Zytnicki, Marcin Bączyk
The paper investigates synapto-nuclear signaling defects in mSOD1 mice and shows that restoring cAMP/PKA signaling mitigates pathology in motoneurons.
bioRxiv · Sep 4, 2026 · PreprintNeuroscience