Author

Samuel Liu

Duke Medical CenterORCID 0000-0001-8339-0080Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alem W. KahsaiiD· 2 shared Ali MasoudiiD· 2 shared Howard A. RockmaniD· 2 shared Natalia PakharukovaiD· 2 shared Robert J. LefkowitziD· 2 shared Seungkirl AhniD· 2 shared Alex Rojas Bie ThomseniD· 1 shared Allison M. SchwalbiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Alem W. KahsaiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 16, 2026

Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules

Samuel Liu, Peng Xiao, Matthias Elgeti…·Robert J. Lefkowitz

The paper identifies and characterizes small molecule allosteric modulators of the AT1R, revealing their conformational mechanisms and effects on G protein and β-arrestin pathways.

DOI 10.64898/2026.07.15.736838

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistryNaturePeer-reviewedJun 24, 2026

Small-molecule modulation of Beta-arrestins

Alem W. Kahsai, Natalia Pakharukova, Henry Y. Kwon…·Robert J. Lefkowitz

This study identifies small-molecule inhibitors of beta-arrestins and elucidates their mechanism, offering a framework for modulating GPCR signaling.

7 citationstop 2%

humanproteomics

𝕏 PostBluesky