Jakub Włodarczyk

The paper investigates how spatial learning remodels the hippocampal palmitoylome in rats, identifying differential palmitoylation changes associated with learning versus general behavioral experience.

This study shows human astrocytes delay neuronal maturation compared to chimpanzee astrocytes, linking astrocyte evolution to brain neoteny and disease vulnerability.

This study shows that S-palmitoylation differentially affects synaptic plasticity and neuronal spiking timing, targeting specific proteins in excitatory synapses.

The paper identifies molecular changes in human astrocytes compared to non-human primates, revealing regulatory mechanisms linked to brain evolution.

The paper investigates stress resilience in mice, showing it involves structural, functional, and molecular changes in synapses, particularly through palmitoylation of synaptic proteins and dendritic spine remodeling.

This study shows neuronal activation remodels nuclear speckles' organization and protein composition in rat hippocampal neurons without causing stress or cell death, and these changes depend on transcription and splicing.

This study identifies phosphorylation of PSD-95 at Serine 73 in dCA1 as necessary for extinction of contextual fear memory.

3dSpAn is a software tool for 3D segmentation and morphological analysis of dendritic spines, addressing segmentation and quantification challenges using multiscale algorithms and feature extraction.

This study identifies plasmin-mediated cleavage of EphA4 at central amygdala inhibitory synapses as a mechanism controlling anxiety through modulation of GABA-receptor anchoring and dendritic spine morphology.

This study shows that phosphorylation of PSD-95 at serine 73 is required for contextual fear extinction but not for fear memory formation or recall.

The paper investigates stress-induced changes in S-palmitoylation and S-nitrosylation of synaptic proteins using a mouse model and a new mass spectrometry-based approach.