Aleksandra Pękowska

This study shows human astrocytes delay neuronal maturation compared to chimpanzee astrocytes, linking astrocyte evolution to brain neoteny and disease vulnerability.

This study compares human and chimpanzee neurons to show that human neurons have altered lipid metabolism and trafficking, contributing to delayed synaptic maturation during brain development.

This study introduces a kinetic model that integrates scRNA-seq and imaging data to simulate gene transcription dynamics and identifies conserved quantities and improved models for transcription factor mechanisms.

The paper identifies molecular changes in human astrocytes compared to non-human primates, revealing regulatory mechanisms linked to brain evolution.

This study shows DIS3 mutations in multiple myeloma increase AID-dependent IgH translocations by altering chromatin interactions and RNA processing.

This study shows that deleting Ncaph2 in mouse hepatocytes does not alter chromatin folding or gene expression, suggesting condensin II's role in interphase may be limited.

This study shows that cohesin removal leads to loss of TADs and loops but preserves compartments, revealing two independent modes of chromosome organization.