Author

Jonathan Miguel Zanatta

Universidade de São PauloORCID 0000-0001-8367-9546Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Sandra Márcia MuxeliD· 3 shared C. A. D. TeixeiraiD· 2 shared Camilla de Almeida Bento· 2 shared Dennyson Leandro M. FonsecaiD· 2 shared Emanuella Sarmento Alho de SousaiD· 2 shared Ian Antunes Ferreira BahiaiD· 2 shared Kathi Terumi KatoiD· 2 shared Maria Regina D’Império LimaiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

Sandra Márcia MuxelORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

microRNA-721 is a host regulator of TNF-IRF1 axis in Leishmania infected macrophage

Jonathan Miguel Zanatta, Ian Antunes Ferreira Bahia, Emanuella Sarmento Alho de Sousa, C. A. D. Teixeira, Kathi Terumi Kato, Camilla de Almeida Bento, Stephanie Maia Acuña, Maria Regina D Lima, Ricardo Silvestre, Dennyson Leandro M. Fonseca, Sandra Márcia Muxel

This study identifies miR-721 as a host regulator that suppresses the TNF-IRF1 axis in Leishmania-infected macrophages, promoting parasite persistence.

bioRxiv · May 16, 2026 · PreprintImmunology

Single-cell RNA sequencing of CTLA-4 and PD-1 blockade in pulmonary paracoccidioidomycosis highlights a protective transcriptional program mediated by activated Th17 cells, neutrophils and macrophages

Sandra Márcia Muxel, Dennyson Leandro M. Fonseca, Ian Antunes Ferreira Bahia, Patrick da Silva, Leonardo Mandu Gonçalves, Emanuella Sarmento Alho de Sousa, Jonathan Miguel Zanatta, C. A. D. Teixeira, Kathi Terumi Kato, Manoela Osorio R Sales, Carlos Neandro Cordeiro Lima, Bruno Prado Eleuterio, Luciana dos Santos Barros Manhães, Bernardo de Castro Oliveira, Nycolas Willian Preite, , Vera Lúcia Garcia Calich

This study uses single-cell RNA sequencing to show that checkpoint inhibitors like anti-CTLA-4 and anti-PD-1 shift the lung immune response in PCM toward a Th17-driven program involving neutrophils and macrophages, enhancing antifungal immunity.

bioRxiv · Jan 23, 2026 · PreprintImmunology

Polyamines shift expression of macrophage L-arginine metabolism related-genes during Leishmania amazonensis infection

Jonathan Miguel Zanatta, Stephanie Maia Acuña, Camilla de Almeida Bento, Beatriz Simonsen Stolf, Sandra Márcia Muxel

The paper shows polyamines alter gene expression related to L-arginine metabolism in macrophages infected with Leishmania amazonensis, affecting parasite survival and immune response.

bioRxiv · May 27, 2022 · PreprintMolecular Biology