Sandra Márcia Muxel

This study identifies HIF-1α as a regulator of metabolic and immunoregulatory programs in RORγt⁺ Tregs during intestinal inflammation, showing its role in maintaining suppressive function and limiting inflammation.

This study identifies miR-721 as a host regulator that suppresses the TNF-IRF1 axis in Leishmania-infected macrophages, promoting parasite persistence.

This study identifies XPC as essential for protecting Th17 cells from oxidative DNA damage, showing its role in DNA repair, differentiation, and function.

This study uses single-cell RNA sequencing to show that checkpoint inhibitors like anti-CTLA-4 and anti-PD-1 shift the lung immune response in PCM toward a Th17-driven program involving neutrophils and macrophages, enhancing antifungal immunity.

The paper shows polyamines alter gene expression related to L-arginine metabolism in macrophages infected with Leishmania amazonensis, affecting parasite survival and immune response.