Maria Regina D’Império Lima

microRNA-721 is a host regulator of TNF-IRF1 axis in Leishmania infected macrophage

This study identifies miR-721 as a host regulator that suppresses the TNF-IRF1 axis in Leishmania-infected macrophages, promoting parasite persistence.

CD39 REGULATES P2RX7-MEDIATED LUNG NECROTIC LESIONS IN SEVERE EXPERIMENTAL TUBERCULOSIS

This study shows CD39 prevents necrotic lung lesions in tuberculosis by inhibiting P2RX7-mediated macrophage death and inflammation.

Single-cell RNA sequencing of CTLA-4 and PD-1 blockade in pulmonary paracoccidioidomycosis highlights a protective transcriptional program mediated by activated Th17 cells, neutrophils and macrophages

This study uses single-cell RNA sequencing to show that checkpoint inhibitors like anti-CTLA-4 and anti-PD-1 shift the lung immune response in PCM toward a Th17-driven program involving neutrophils and macrophages, enhancing antifungal immunity.

Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses

This study shows that exposure to ETEC or its toxin LT reduces lung allergic inflammation by inhibiting IL-33 responses in ILC2 cells through a gut-derived negative feedback loop.

Sensing of extracellular ATP via P2RX7 drives lung tumor growth through regulatory T cell suppressive function

This study identifies P2RX7 as a key regulator of Treg suppressive function in lung tumors, showing that targeting P2RX7 could improve lung cancer treatment by reducing Treg-mediated immune suppression.