Afshan McCarthy

The paper shows that inhibiting ERK signaling expands epiblast cells capable of becoming naive pluripotent stem cells in humans, while FGF stimulation expands hypoblast markers.

The paper investigates PADI6's role in oocyte cytoplasmic lattices using single-cell proteomics and transcriptomics, revealing its critical scaffolding function and connections to other oocyte compartments.

This study uses live imaging to show mitotic errors and lineage plasticity in human embryos before implantation, revealing implications for aneuploidy mosaicism.

The paper identifies transcription factors that can convert human embryonic stem cells into trophoblast stem cells, revealing their role in early placental development.

The paper evaluates gene regulatory network prediction methods in early human embryos, finding that MICA, combining mutual information with chromatin accessibility, provides more reproducible and biologically meaningful results.

This study shows that human blastoids and pluripotent stem cells can enter a dormant state via mTOR inhibition, with distinct temporal dynamics compared to mice.

The paper investigates the conservation of Hippo signaling in the first lineage specification event across four mammalian species, finding that inhibiting the Hippo pathway drives ectopic trophectoderm initiation in all species.

The paper shows KLF17 can induce a naive-like transcriptome in primed hESCs but is not required for naive pluripotency establishment in vitro.

The paper analyzes single-cell genomics and transcriptomics data from CRISPR-Cas9-edited human embryos to assess unintended editing outcomes and loss-of-heterozygosity.