Roger B Sutton

The paper identifies germ granule-like amyloid/RNA condensates in rat epididymal spermatozoa that exhibit prion-like propagation activity, suggesting a non-Mendelian mechanism for transmitting environmental information to offspring.

The paper models how AD3 mutations in synaptotagmin 1's C2 domains affect Ca2+ binding pocket dynamics and explains their lethal effects through increased loop mobility and volume changes.