Chantell S. Evans

In rat hippocampal neurons under mild oxidative stress, Optineurin-marked damaged mitochondria are engulfed slowly and reach lysosomes over days; scavenging mitochondrial reactive oxygen species or nutrient deprivation speeds this.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

This study investigates how MICOS disruption affects mitochondrial structure and function in neurons vulnerable to Alzheimer's disease, linking these changes to early mitochondrial dysfunction and neuronal vulnerability.

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

The paper shows that LRRK2 mutations disrupt autophagosome transport in neurons by creating a tug-of-war between dynein and kinesin motors, contributing to Parkinson's disease pathogenesis.

This study shows that SYT9 regulates spontaneous neurotransmitter release in striatal neurons by controlling substance P secretion, without triggering rapid synaptic vesicle exocytosis.

The paper models how AD3 mutations in synaptotagmin 1's C2 domains affect Ca2+ binding pocket dynamics and explains their lethal effects through increased loop mobility and volume changes.