Edwin R. Chapman

This study shows that alternative splicing of synaptotagmin 7 affects its oligomerization and function in short-term synaptic plasticity.

This study investigates how Munc18 influences the order and pathway of SNARE complex assembly, revealing a concerted mechanism that promotes functional fusion.

This study shows that Doc2 and Syt7 knockout mice exhibit increased CA3 burst activity, suggesting their role in regulating network activity rather than neurotransmitter release.

This study shows that the juxtamembrane linker of synaptotagmin 1 mediates liquid-liquid phase separation, which modulates Ca2+ binding and synaptic vesicle exocytosis.

This study compares synaptotagmin-1 and synaptotagmin-7, finding that synaptotagmin-7 more effectively penetrates membranes and stabilizes fusion pores during exocytosis.

This study identifies Doc2 as the major Ca2+ sensor for asynchronous release and shows that syt7 supports vesicle docking, with combined effects on synaptic function.

This study shows that SYT9 regulates spontaneous neurotransmitter release in striatal neurons by controlling substance P secretion, without triggering rapid synaptic vesicle exocytosis.

The paper shows that synaptic vesicle proteins selectively enter axons and are delivered to presynaptic membranes before being incorporated into vesicles, challenging the selective retention model.

The paper characterizes N-glycosylation at synaptic vesicles and neuronal plasma membranes in mouse brain, identifying highly fucosylated N-glycans enriched in synaptic vesicles.

The paper investigates mitochondrial trafficking and fusion in rat hippocampal axons, showing that mitochondrial complementation supports synaptic vesicle cycle function.

This study shows that interneuronal α5-GABAARs promote spatial learning and mediate etomidate's suppression of hippocampus-dependent memory.

This study shows that synaptotagmin-1 multimerization via the juxtamembrane linker is essential for both spontaneous and evoked neurotransmitter release.

This study investigates the role of SYT7 in synaptic function by analyzing its localization and effects on vesicle docking and synaptic plasticity in mouse hippocampal neurons.

This study shows that polybasic patches in both C2A and C2B domains of Synaptotagmin-1 are required for evoked neurotransmitter release, but not for spontaneous release or the readily releasable vesicle pool.

The paper introduces variants of the glutamate sensor iGluSnFR with improved brightness, broader concentration detection, and different emission colors for enhanced in vivo imaging.

The paper models how AD3 mutations in synaptotagmin 1's C2 domains affect Ca2+ binding pocket dynamics and explains their lethal effects through increased loop mobility and volume changes.