Annat Haber

The paper presents the first telomere-to-telomere genome for the common marmoset, revealing genomic features and a pangenome resource for biomedical research.

This study shows that PSEN1 mutant marmoset fibroblasts exhibit multi-omic signatures similar to Alzheimer's disease in humans, highlighting sex-specific differences and disease-relevant pathways.

This study shows that human KL haplotypes FC and VS cause widespread transcriptomic changes in mouse brains at 12 months old, affecting mitochondrial, ribosomal, and synaptic functions, and linking them to Alzheimer's Disease pathogenesis.

This study compares two mouse models of TREM2 variants, showing both mimic Alzheimer's disease signatures in similar biological domains.

The paper examines how histone modifications vary across mouse strains and correlates these variations with gene expression, finding strong links between chromatin states and gene expression, but not DNA methylation.

This study identifies novel genetic modifiers of late-onset Alzheimer's disease by stratifying patients into molecular subtypes using transcriptomic data and whole genome sequencing.