Catrina A. Spruce

The paper presents the first telomere-to-telomere genome for the common marmoset, revealing genomic features and a pangenome resource for biomedical research.

This study shows that PSEN1 mutant marmoset fibroblasts exhibit multi-omic signatures similar to Alzheimer's disease in humans, highlighting sex-specific differences and disease-relevant pathways.

This study shows that human KL haplotypes FC and VS cause widespread transcriptomic changes in mouse brains at 12 months old, affecting mitochondrial, ribosomal, and synaptic functions, and linking them to Alzheimer's Disease pathogenesis.

Enhlink infers enhancer-promoter linkages using scATAC-seq data and outperforms existing methods, revealing a super-enhancer regulating striatal neuron markers.

The paper examines how histone modifications vary across mouse strains and correlates these variations with gene expression, finding strong links between chromatin states and gene expression, but not DNA methylation.

The paper shows genetic variation in mouse ESCs affects lineage commitment by modulating pluripotency epigenome regulators, with B6 and D2 strains showing distinct differentiation biases.

The paper shows HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hotspots, enabling DSB machinery access and preventing sterility in male mice.

The paper identifies genetic variants influencing metastability in mouse embryonic stem cells by analyzing gene expression and chromatin accessibility in 185 genetically diverse cells.

The paper identifies tissue-specific trans-regulation of H3K4me3 levels in mouse cell types and links it to histone quantitative trait loci (hQTL) associated with zinc finger genes.