Author

Helen F. Dietmar

Heidelberg UniversityORCID 0000-0001-8409-3221Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Solvig DiederichsiD· 2 shared Wiltrud RichteriD· 2 shared Andrea VortkampiD· 1 shared Attila AszódiiD· 1 shared C. Binder· 1 shared Felicia A. M. KlampfleuthneriD· 1 shared Matthias GerstneriD· 1 shared Nicole Hecht· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

Solvig DiederichsORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 2, 2025

Dichotomous SMAD2/3 regulation and selective anti-hypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells

Sven Christian Schmidt, Safak Chasan, Helen F. Dietmar…·Solvig Diederichs

This study shows that heparin promotes endochondral differentiation of MSCs in vitro but chondral development in vivo, with selective anti-hypertrophic effects through SMAD2/3 regulation.

DOI 10.1101/2025.09.02.673657

humanproteomics

𝕏 PostBluesky

Cell BiologyMatrix BiologyPeer-reviewedMay 14, 2025

Load activated FGFR and beta1 integrins target distinct chondrocyte mechano-response genes

Helen F. Dietmar, Pia A. Weidmann, Paolo Alberton…·Solvig Diederichs

This study identifies distinct mechano-response genes regulated by load-activated FGFR and beta1 integrins in chondrocytes, showing they control different subsets of genes.

5 citations

mousehuman

𝕏 PostBluesky

Cell BiologybioRxivPreprintOct 11, 2024

The neuropeptide alpha calcitonin gene-related peptide impairs load-stimulated proteoglycan production of human chondrocytes via WNT activity

Helen F. Dietmar, Nicole Hecht, C. Binder…·S. Diederichs

This study shows that CGRP impairs load-stimulated proteoglycan production in human chondrocytes by modulating WNT activity, suggesting a new therapeutic target for osteoarthritis.

DOI 10.1101/2024.10.11.617807

humanproteomics

𝕏 PostBluesky