Author

Sven Christian Schmidt

Heidelberg UniversityORCID 0000-0003-0558-4001Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Solvig DiederichsiD· 3 shared Felicia A. M. KlampfleuthneriD· 2 shared Wiltrud RichteriD· 2 shared Christian MerleiD· 1 shared Helen F. DietmariD· 1 shared Safak ChasaniD· 1 shared Sarah Anna Nüesch· 1 shared Simon I. DreheriD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

Solvig DiederichsORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 2, 2025

Dichotomous SMAD2/3 regulation and selective anti-hypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells

Sven Christian Schmidt, Safak Chasan, Helen F. Dietmar…·Solvig Diederichs

This study shows that heparin promotes endochondral differentiation of MSCs in vitro but chondral development in vivo, with selective anti-hypertrophic effects through SMAD2/3 regulation.

DOI 10.1101/2025.09.02.673657

humanproteomics

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Cell BiologyEuropean Journal of Cell BiologyPeer-reviewedApr 7, 2024

Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis

Sven Christian Schmidt, Felicia A. M. Klampfleuthner, Tobias F. Renkawitz, Solvig Diederichs

This study investigates the role of PGE2 in MSC chondrogenesis, showing it has chondroprotective effects despite being driven by prohypertrophic signals.

9 citations

experimental assaycell signaling & trafficking

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Cell BiologyStem Cell Research & TherapyPeer-reviewedApr 5, 2024

Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: A revision of the prohypertrophic signalling network concept

Solvig Diederichs, Simon I. Dreher, Sarah Anna Nüesch…·Wiltrud Richter

This study investigates the role of ALK1/2/3 inhibition in mesenchymal stromal cell chondrogenesis, finding that BMP-ALK1/2/3 signaling is not a driver of hypertrophy and that PTHrP/hedgehog and WNT signaling are more critical in hypertrophic differentiation.

6 citations

humanbulk RNA-seq

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