Author

S. Diederichs

Heidelberg University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

S. Schmidt· 3 shared W. Richter· 2 shared A. Goncalves· 1 shared A. K. Miller· 1 shared A. Kopp-Schneider· 1 shared A. Teleman· 1 shared C. Binder· 1 shared C. Brandstaedter· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

S. Schmidt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The neuropeptide alpha calcitonin gene-related peptide impairs load-stimulated proteoglycan production of human chondrocytes via WNT activity

Helen F. Dietmar, Nicole Hecht, C. Binder, S. Schmidt, T. Walker, S. Grässel, W. Richter, S. Diederichs

This study shows that CGRP impairs load-stimulated proteoglycan production in human chondrocytes by modulating WNT activity, suggesting a new therapeutic target for osteoarthritis.

bioRxiv · Oct 11, 2024 · PreprintCell Biology

Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: A revision of the prohypertrophic signalling network concept

S. Diederichs, S. I. Dreher, S.-A. Nueesch, S. Schmidt, C. Merle, W. Richter

This study investigates the role of ALK1/2/3 inhibition in mesenchymal stromal cell chondrogenesis, finding that BMP-ALK1/2/3 signaling is not a driver of hypertrophy and that PTHrP/hedgehog and WNT signaling are more critical in hypertrophic differentiation.

bioRxiv · Mar 12, 2024Cell Biology

Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis

S. Schmidt, F. A. Klampfleuthner, T. Renkawitz, S. Diederichs

This study investigates the role of PGE2 in MSC chondrogenesis, showing it has chondroprotective effects despite being driven by prohypertrophic signals.

bioRxiv · Jan 20, 2024Cell Biology

Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs

J. Samarin, P. Fabrowski, R. Kurilov, H. Nuskova, J. Hummel-Eisenbeiss, H. Pink, N. Li, V. Weru, H. Alborzinia, U. Yildiz, L. Grob, M. Taubert, M. Czech, M. Morgen, C. Brandstaedter, , N. Gunkel

The paper identifies antioxidant-capacity biomarkers (ACBs) that predict susceptibility to ROS-inducing drugs in lung cancer cells, showing that low ACB expression correlates with nitric oxide levels, not ROS levels.

bioRxiv · Jan 17, 2023Cancer Biology