Moritz A. Middelhoff

This study examines how bile acid modulation affects colonic epithelial responses in mice and humans, finding altered cell populations and gene expression associated with DCA exposure.

The paper identifies Dclk1-expressing cells in the pancreas and reveals their role in inhibiting pancreatic tumor progression through a tuft cell-ILC2 axis.

This study challenges the traditional model of intestinal stem cells by showing that Lgr5+ cells are not the sole stem cell compartment and that stemness exists in the isthmus region, contributing to homeostasis and regeneration.