A bivalent lysine-acetylated small-molecule binding site in MYC
Dikshat Gopal Gupta, Mihai Ioan Truica, Jin‐gon Shim, J. Brandon Parker, Mahil Lambert, Adam W. T. Steffeck, Daniel Herald Ryan, Hao Pan, Kerem Kahraman, Xinyan Lu, William Yang, Kenji Unno, Ala A. Elmashae, Megan M. Kerber, Caitlyn Elysse Brookins, , Sarki Abba Abdulkadir
This study identifies a bivalent binding site in MYC for small-molecule inhibitors and shows acetylation enhances inhibitor binding and oncogenic activity.
bioRxiv · Aug 18, 2026 · PreprintCancer Biology