Kerem Kahraman

A bivalent lysine-acetylated small-molecule binding site in MYC

This study identifies a bivalent binding site in MYC for small-molecule inhibitors and shows acetylation enhances inhibitor binding and oncogenic activity.

Intrinsic conformational equilibria position arrestin-2 for activation

This study identifies two distinct conformational equilibria in arrestin-2 that underlie its pre-activation state in solution.

Dynamic hotspots in the Uba7 UFD direct UbcH8 recognition

This paper presents the NMR structure and functional analysis of the Uba7 UFD domain and its interaction with UbcH8, revealing structural flexibility and key residues critical for E2 recognition in the ISGylation pathway.

Exploring the Biochemical Landscape of Bacterial Medium with Pyruvate as the Exclusive Carbon Source for NMR Studies

This study investigates E. coli metabolism on pyruvate as the sole carbon source for NMR studies, revealing metabolic inefficiencies that impact isotopic labeling.