Author
Northwestern UniversityORCID 0000-0003-4180-5051Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Dikshat Gopal Gupta, Mihai Ioan Truica, Jin‐gon Shim…·Sarki Abba Abdulkadir
This study identifies a bivalent binding site in MYC for small-molecule inhibitors and shows acetylation enhances inhibitor binding and oncogenic activity.
Paige J. Monsen, Prashant V. Bommi, Arabela A. Grigorescu…·Gary E. Schiltz
This study optimizes a PROTAC to degrade IDO1 with high potency in GBM cells, showing sustained degradation via the ubiquitin-proteasome system.
Fangfang Qiao, T.A. Binkowski, Irene Broughan…·Raymond C. Bergan
The paper uses protein 3D structure analysis to discover novel anticancer compounds by targeting unique structural motifs, identifying Dxr2-017 as a selective inhibitor of melanoma cells.
Brenda C. Shields, Hai Yan, Shaun S.X. Lim…·Michael R. Tadross
The paper introduces DART.2, a method for cell-specific drug delivery, demonstrating robust bidirectional editing of neurotransmission in mice.