NeurosciencebioRxivPreprint
Exploiting threonine sidechains as molecular switches to modulate the fluorescence of genetically encoded biosensors
Lee Min Leong, Sang Chul Shin, Jun Kyu Rhee…·Bradley James Baker
The paper develops a novel GEVI that brightens upon depolarization by manipulating threonine sidechains to control chromophore conformation and fluorescence transitions.
DOI 10.1101/2022.04.25.489330