Jason Lee

The paper develops a halide-sensitive YFP quenching assay to functionally validate BEST1 variants and distinguish loss-of-function from gain-of-function mutations.

This study shows that mechanical conditioning improves the regenerative potential of aged mesenchymal stem cells by reducing senescence and altering their genetic landscape.

The paper identifies small molecules that synergize with mechanical loading to prime pluripotency in mouse fibroblasts using high throughput mechanobiological screens.