Aaron B. Baker

This paper develops a computational model to simulate mechanical stretching of cultured cells on a flexible membrane and connects it to chromatin deformation.

This study shows that dynamically adjusting hydrogel stiffness during vasculogenesis improves vascular network formation, while late stiffening disrupts it, with effects mediated by FAK and Rho kinase.

This study shows that mechanical conditioning improves the regenerative potential of aged mesenchymal stem cells by reducing senescence and altering their genetic landscape.

The paper identifies small molecules that synergize with mechanical loading to prime pluripotency in mouse fibroblasts using high throughput mechanobiological screens.