Marta Olejniczak

This study generates an isogenic iPSC panel to investigate ATN1's role in human development and disease, revealing proliferation deficits and toxic gain-of-function effects in mutant ATN1 lines.

This paper introduces 3TRS, a targeted RNA sequencing method to quantify HTT transcripts in HD models, revealing cryptic polyadenylation linked to somatic instability and CAG repeat purity.

The paper introduces miRarchitect, a machine learning platform for designing artificial microRNAs, showing it produces functional amiRNAs more effectively than existing tools.

This study identifies DCLRE1A as a key factor in CAG repeat contraction following Cas12a-induced DNA breaks and demonstrates its role in enhancing repeat shortening through interactions with repair proteins.

This study shows that CRISPR/Cas9-induced DSBs in the huntingtin locus cause CAG repeat contraction through DNA end resection and homology-mediated repair in human cells.