Lorea Blázquez

This study shows that ARC acts as a retroviral-like capsid for TDP-43 spreading in ALS and FTD, and that Lenacapavir blocks this process.

This paper introduces 3TRS, a targeted RNA sequencing method to quantify HTT transcripts in HD models, revealing cryptic polyadenylation linked to somatic instability and CAG repeat purity.

This study shows that LKB1 deletion in mouse pancreatic beta cells causes widespread chromatin accessibility changes and affects gene expression, including neuronal genes.

This paper introduces a CRISPR-dCas13 tool to manipulate alternative splicing patterns and identify regulatory RNA elements in a cost-effective manner.

ORC1 binds to cis-transcribed RNAs from genes with replication origins at TSSs, which is required for optimal origin activation.