Targeted 3'-end RNA sequencing uncovers cryptic polyadenylation in Huntington's disease linked to somatic instability and CAG repeat purity
Ane Velasco-Bilbao, María Manterola, Álvaro Herrero-Reiriz, Maria Carazo-Hidalgo, Anna Misiukiewicz, Olatz Arnold-García, Esther Pérez‐Navarro, Martina Hallegger, Jernej Ule, Alberto Rábano, Adolfo López de Munain, Marta Olejniczak, Verónica Brito, Lorea Blázquez
This paper introduces 3TRS, a targeted RNA sequencing method to quantify HTT transcripts in HD models, revealing cryptic polyadenylation linked to somatic instability and CAG repeat purity.
bioRxiv · Apr 16, 2026 · PreprintMolecular Biology