Amy C. Rosenzweig

The paper differentiates 5-thiooxazoles from oxazolone-coupled thioamides in RiPP natural products using chemical and structural analysis of oxazolin and methanobactin.

The paper identifies a novel RiPP biosynthetic pathway in Streptomyces thermodiastaticus involving a YcaO-TfuA pair, a carbamoyltransferase, and a MNIO enzyme that bis-hydroxylates homocitrulline.

This paper investigates the iron cofactor in the MNIO enzyme HvfB involved in oxazolin biosynthesis, revealing a mixed-valent diiron(II/III) cluster essential for 5-thiooxazole formation.

The paper shows that mechanosensitive channels in prokaryotes, like E. coli, mediate copper influx, challenging the idea that cytoplasmic copper uptake is unnecessary in these organisms.