Author

Brian M. Hoffman

Northwestern UniversityORCID 0000-0002-3100-0746Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 2 Organism:bacteria (other)· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Amy C. RosenzweigiD· 1 shared Brian B. BothneriD· 1 shared Brian BennettiD· 1 shared Edwin AntonyiD· 1 shared Jaigeeth DeveryshettyiD· 1 shared Kewei ZhaoiD· 1 shared Madeline B. HoiD· 1 shared Monika Tokmina‐LukaszewskaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Amy C. RosenzweigORCID

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2 papers

Recent·Most cited

Thiooxazole Formation on a Nontypeable Haemophilus influenzae Virulence Factor Requires a Mixed-Valent Diiron Cofactor

Olivia M. Manley, Madeline B. Ho, Patrick M McLean, Philip M. Palacios, Yisong Guo, Brian M. Hoffman, Amy C. Rosenzweig

This paper investigates the iron cofactor in the MNIO enzyme HvfB involved in oxazolin biosynthesis, revealing a mixed-valent diiron(II/III) cluster essential for 5-thiooxazole formation.

bioRxiv · Jul 20, 2026 · PreprintBiochemistry

Cryo-EM captures the coordination of long-range allostery and asymmetric electron transfer by a bi-copper cluster in the nitrogenase-like DPOR complex

Rajnandani Kashyap, Natalie Walsh, Jaigeeth Deveryshetty, Monika Tokmina‐Lukaszewska, Kewei Zhao, Yunqiao J. Gan, Brian M. Hoffman, Ritimukta Sarangi, Brian B. Bothner, Brian Bennett, Edwin Antony

The paper uses Cryo-EM to reveal how asymmetry and allostery coordinate long-range electron transfer in the DPOR enzyme through a bi-copper cluster.

Nature Communications · Apr 24, 2025Peer-reviewedBiochemistry