Rodolfo García‐Contreras

Comparative genomics of clinical isolates of Pseudomonas aeruginosa from cystic fibrosis patients in Mexico

This study analyzes 41 Pseudomonas aeruginosa isolates from CF patients in Mexico to characterize their resistance, virulence, and evolutionary dynamics using genomic and phylogenomic methods.

Azelaic Acid as a Novel Antivirulence Agent Against Pseudomonas aeruginosa: In silico, In vitro and In vivo Efficacy and Biocompatibility

This study shows azelaic acid reduces Pseudomonas aeruginosa virulence factors without killing bacteria, with safety and molecular docking support.

Curcumin and 5-bromoindole-3-carboxaldehyde inhibit the production of Quorum sensing-dependent virulence factors in Pseudomonas aeruginosa

This study evaluates curcumin and 5-bromoindole-3-carboxaldehyde for inhibiting quorum sensing-dependent virulence factors in Pseudomonas aeruginosa strains.

Engineering Methyl-Coenzyme M Reductase for Enhanced Methane and Carbon Dioxide Capture through Biofilm Growth

This paper engineers methyl-coenzyme M reductase (Mcr) to enhance methane and carbon dioxide capture by identifying beneficial substitutions that improve biofilm growth and methane capture.

Enhancing Reverse Methanogenesis Using RNA-Guided Silencing

The paper enhances reverse methanogenesis by silencing the native Mcr gene in engineered archaea to boost methane conversion into ethanol and acetate.

Resistome, Virulome, Mobilome, And Biosynthetic Gene Clusters Adaptations of Acinetobacter Baumannii Mexican Strains Across the Pre- and of the COVID-19 Period: Insights from Whole-Genome Sequencing

This study compares the genomic adaptations of Acinetobacter baumannii strains in Mexico before and during the COVID-19 period using whole-genome sequencing, revealing increased resistance genes, virulence factors, and mobilome elements.

Persister Cells Form Based on Low Ribosome Content

The paper shows that cells with low ribosome content form persister cells 80-fold more frequently than average, indicating persister formation is inversely related to ribosome abundance.

Serine Recombinase PinR Inverts Cryptic Prophage DNA to Block Adsorption of Phages

The paper identifies PinR, a serine recombinase in E. coli, which inverts prophage DNA to block T2 phage infection by creating a protein that prevents phage receptor binding.

Toxin/Antitoxin Systems Induce Persistence and Work in Concert with Restriction/Modification Systems to Inhibit Phage

The paper shows toxin/antitoxin systems induce persister cells to inhibit phage, working with restriction-modification systems to inactivate phage DNA.

Single-Cell Analysis Reveals Cryptic Prophage Protease LfgB Protects Escherichia coli During Oxidative Stress by Cleaving Antitoxin MqsA

The paper uses single-cell analysis to show that the MqsR/MqsA TA system in E. coli protects against oxidative stress via the cryptic prophage protease LfgB, which degrades MqsA to activate stress response genes.