Benedikt G. Brink

The paper presents an allele-specific genome assembly for Trypanosoma brucei, enabling analysis of allele-specific mechanisms and improving genome assembly benchmarks for highly heterozygous species.

The paper identifies a novel mechanism in trypanosomes where inter-chromosomal interactions between an antigen coding gene and an mRNA splicing locus ensure monogenic antigen expression.

This paper describes an oligo-based method for efficiently depleting rRNA from trypanosomal samples, achieving less than 5% rRNA levels with minimal off-target effects.