Joana R. Correia Faria

This paper identifies SUMOylation as a key regulator of ESB organization and antigenic variation in Trypanosoma brucei by showing its role in maintaining transcriptional compartments and VSG gene expression.

This study uses CRISPR-Cas9 to edit phosphosite codons in kinetochore proteins of Leishmania mexicana, finding no growth defects in phosphosite mutants.

The paper identifies three proteins that negatively regulate ESAG transcripts through specialised RNA decay in Trypanosoma brucei, revealing a novel post-transcriptional regulatory mechanism.

The paper shows that VSG transcripts play a non-coding role in allelic exclusion in trypanosomes by participating in allelic competition.

This study maps DNA G-quadruplexes in Trypanosoma brucei, showing enrichment in coding regions and functional impact of G4-stabilizing ligands on gene expression.

The paper shows that specific histone H4 lysine mutations disrupt polycistronic gene expression in trypanosomes by altering promoter-associated chromatin structure.

The paper identifies a novel mechanism in trypanosomes where inter-chromosomal interactions between an antigen coding gene and an mRNA splicing locus ensure monogenic antigen expression.