Author

Dmitri Kireev

University of North Carolina at Chapel HillORCID 0000-0001-8479-8555Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Brian P. HardyiD· 2 shared Stephen V. FryeiD· 2 shared A.M. EdwardsiD· 1 shared Aiping DongiD· 1 shared Akhila MettuiD· 1 shared Albina Bolotokova· 1 shared Aleksandra IvanováiD· 1 shared Alexander FürlliD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Brian P. HardyORCID

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3 papers

Recent·Most cited

BiochemistryJournal of Chemical Information and ModelingPeer-reviewedNov 5, 2024

CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson's Disease associated protein.

Fengling Li, Suzanne Z. Ackloo, C. H. Arrowsmith…·Matthieu Schapira

The paper evaluates computational hit-finding methods for targeting the WDR domain of LRRK2, a Parkinson's disease protein, finding that diverse strategies yielded weakly potent compounds.

34 citationstop 4%

deep learningdrug response / drug discovery

𝕏 PostBluesky

NeuroscienceAlzheimer s & Dementia Translational Research & Clinical InterventionsPeer-reviewedJan 1, 2022

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

Frances Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé…·Alison Donnelly Axtman

The paper compiles an annotated set of 171 small molecule modulators targeting 98 novel AD therapeutic proteins, serving as chemical tools for hypothesis validation.

6 citations

statistical modeldrug response / drug discovery

𝕏 PostBluesky

Synthetic BiologyCell chemical biologyPeer-reviewedOct 28, 2021

REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR

Junghyun L. Suh, Daniel Bsteh, Bryce Hart…·Oliver Bell

This paper identifies UNC7040 as a potent CBX8-specific positive allosteric modulator that disrupts PRC1 function and reduces cancer cell proliferation.

26 citations

ChIP-seqexperimental assay

𝕏 PostBluesky