Author
University of California, San FranciscoORCID 0000-0001-8490-2543Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Amanda McQuade, Vincent Cele Castillo, Venus Hagan…·Martin Kampmann
This study identifies 772 genes regulating the interferon-responsive microglia state using CRISPRi screening in human iPSC-derived microglia, including novel regulators like CNOT10.
Amanda McQuade, Reet Mishra, Venus Hagan…·Martin Kampmann
The paper identifies regulators of microglial activation states using CRISPR screens and single-cell transcriptomics, revealing functional roles of ZNF532, PRDM1, and DNMT1 in disease-associated microglial states.
Olivia M. Teter, Amanda McQuade, Venus Hagan…·Martin Kampmann
The paper uses CRISPRi to screen ASD risk genes in microglia, identifying ADNP's role in synaptic pruning and endocytosis.
Emmy Li, Camila Benitez, Steven C. Boggess…·Martin Kampmann
The paper develops iAssembloids to study neuron-glia interactions using CRISPRi screens and finds GSK3β inhibits NRF2-mediated oxidative stress response and APOE-4 promotes neuronal activity.
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang…·Martin Kampmann
This study uses a CRISPRi/a platform in iPSC-derived microglia to identify genes regulating microglia states and their therapeutic targets.