Steven C. Boggess

Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation

The paper uses multi-omic analysis to study MAPT V337M neurons, finding altered axonogenesis and tau phosphorylation, with p38 MAPK pathway involvement in tau phosphorylation in V337M neurons.

A genetic screen in enteroendocrine cells reveals mechanisms that control protein sensing and GLP-1 release

This study identifies mitochondrial respiration genes as critical for protein sensing and GLP-1 release in enteroendocrine cells through a CRISPR screen.

CRISPRi-based screen of Autism Spectrum Disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning

The paper uses CRISPRi to screen ASD risk genes in microglia, identifying ADNP's role in synaptic pruning and endocytosis.

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions

The paper develops iAssembloids to study neuron-glia interactions using CRISPRi screens and finds GSK3β inhibits NRF2-mediated oxidative stress response and APOE-4 promotes neuronal activity.

A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity

The paper develops a CRISPRi-based screening platform to identify genes affecting neuronal excitability in human iPSC-derived neurons, revealing new links to neurodegenerative and neurodevelopmental disorders.